Role of neuron and non-neuronal cell communication in persistent orofacial pain
Iwata Koichi, Shinoda Masamichi,
소속 상세정보
( Iwata Koichi ) - Nihon University School of Dentistry Department of Physiology
( Shinoda Masamichi ) - Nihon University School of Dentistry Department of Physiology
Abstract
It is well known that trigeminal nerve injury causes hyperexcitability in trigeminal ganglion neurons, which become sensitized. Long after trigeminal nerve damage, trigeminal spinal subnucleus caudalis and upper cervical spinal cord (C1/C2) nociceptive neurons become hyperactive and are sensitized, resulting in persistent orofacial pain. Communication between neurons and non-neuronal cells is believed to be involved in these mechanisms. In this article, the authors highlight several lines of evidence that neuron-glial cell and neuron macrophage communication have essential roles in persistent orofacial pain mechanisms associated with trigeminal nerve injury and/or orofacial inflammation.
키워드
Cell Communication; Orofacial Persistent Pain; Spinal Trigeminal Nucleus; Trigeminal Ganglion
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